| Disease Name : | Gastric cancer |
| Regulator : | HOXA11-AS |
| Target : | CTNNB1 |
| Clinical application : | metastasis |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | DOWN(LIHC,NSCLC,PRAD,PAAD,BRCA);UP(SKCM);DATA(GSE117623,GSE74639,GSE104209,GSE60407,GSE38495,GSE111842,GSE51827,GSE55807,GSE86978) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | positively-E |
| Experimental method for lncRNA-target : | ChIP;RIP |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | microarray;sequencing |
| Data Accession : | |
| Influenced Function : | cell proliferation(+);cell invasion(+) |
| Regulatory Mechanism : | histone modification |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Insensitivity to Antigrowth Signals;Tissue Invasion and Metastasis |
| Disease Category : | Cancer |
| Disease Name2 : | Gastric cancer |
| Regulator Type : | lncRNA |
| Target Type : | PCG |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000168036 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 1499 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | CTNNB|EVR7|MRD19|NEDSDV|armadillo |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer. Mechanistic investigation showed that HOXA11-AS could interact with WDR5 and promote beta-catenin transcription, bind with EZH2 and repress P21 transcription, and induce KLF2 mRNA degradation via interacting with STAU1.These findings show that HOXA11-AS not only could promote GC cells migration and invasion in vitro, but also promotes GC cells metastasis in vivo, at least in part, by regulating beta-catenin and KLF2. |
| PubMedID : | 28441948 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | CTNNB1 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 120.9907986 | -0.158320171 | 0.384551232 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 187.2645585 | -0.254752513 | 3.84e-05 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 115.3816455 | -0.443670859 | 0.471878706 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 86.65425722 | -0.4182075 | 0.175579894 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 198.2491242 | 0.499403265 | 4.67e-10 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 144.380922 | 0.362079227 | 0.111246289 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 190.7633146 | 0.5541033 | 0.004672284 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 125.1457982 | -0.271092944 | 0.005331434 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 59.58546318 | -0.256190757 | 0.038023606 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 120.8245102 | -0.198789534 | 0.00432218 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 75.792897 | -0.519883901 | 4.61e-07 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 67.74763417 | 0.055252418 | 0.602493449 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 190.5728371 | 0.204856108 | 0.032083266 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 149.1709542 | -0.205163818 | 0.021466673 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 160.4921297 | 0.082741433 | 0.912872541 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 68.29641599 | -0.923378368 | 0.05383235 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 129.1658689 | -0.225208405 | 0.00011253 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 215.2819245 | 0.530468998 | 0.001302647 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 155.5045979 | 0.287460631 | 0.810983212 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 339.1089225 | 0.621083734 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 123.9576538 | 0.376457716 | 0.003075162 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 202.3168574 | 0.689925934 | 2.72e-21 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 107.0377266 | 0.275767047 | 0.86984365 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 112.2448717 | -0.279497623 | 0.031092773 |
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