| Disease Name : | Hepatocellular carcinoma |
| Regulator : | HOXA11-AS |
| Target : | LATS1 |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | DOWN(NSCLC,PRAD,PAAD,SKCM,BRCA);UP(PAAD);DATA(GSE74639,GSE40174,GSE104209,GSE60407,GSE38495,GSE111842,GSE109761,GSE111065,GSE51827,GSE55807,GSE75367,GSE86978) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | negatively-E |
| Experimental method for lncRNA-target : | western blot;ChIP |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell proliferation(+) |
| Regulatory Mechanism : | histone modification |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Insensitivity to Antigrowth Signals |
| Disease Category : | Cancer |
| Disease Name2 : | Liver cancer |
| Regulator Type : | lncRNA |
| Target Type : | PCG |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000131023 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 9113 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | WARTS|wts |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Promotion of LncRNA HOXA11-AS on the proliferation of hepatocellular carcinoma by regulating the expression of LATS1;RIP and CHIP experiments showed that HOXA11-AS inhibited the expression of LATS1 genes by binding enhancer of zeste homolog 2 (EZH2) proteins |
| PubMedID : | 28829501 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | LATS1 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 4.523503372 | -0.441609207 | 0.004063421 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 9.503080969 | -0.295113962 | 1.34e-05 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 5.054800596 | -0.441295183 | 0.364135367 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 4.75621049 | -0.121481509 | 0.684870933 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 5.055981064 | 0.016871677 | 0.87875588 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 12.98349251 | -0.043201498 | 0.825262969 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 5.580474789 | -0.129680925 | 0.648839569 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 6.642626962 | 0.01164447 | 0.919428583 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 3.381726719 | -0.22120491 | 0.061711925 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 6.944124971 | -0.225306626 | 0.000139867 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 4.756529464 | -0.326511804 | 0.00116575 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 2.321401957 | -0.345069417 | 0.000652267 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 6.015483828 | -0.218389431 | 0.0018257 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 7.3816957 | 0.015347387 | 0.858552763 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 5.307970389 | -0.227078847 | 0.729181217 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 5.408297566 | -0.166765458 | 0.658698513 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 8.194984471 | -0.210827995 | 0.015703478 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 5.012225377 | -0.165106666 | 0.41390192 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 7.747334795 | 0.620592757 | 0.566871622 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 4.672353542 | 0.329139348 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 9.212676271 | 0.082640206 | 0.378014223 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 6.145069967 | -0.073887044 | 0.244606145 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 5.302046635 | -0.453452188 | 0.773495224 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 4.757258799 | -0.585413285 | 5.03e-08 |
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