| Disease Name : | Non-small cell lung cancer |
| Regulator : | HOXA11-AS |
| Target : | SP1 |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | DOWN(LIHC,NSCLC,PRAD,PAAD,SKCM,BRCA);UP(PAAD);DATA(GSE117623,GSE74639,GSE40174,GSE104209,GSE60407,GSE38495,GSE111842,GSE109761,GSE111065,GSE51827,GSE55807,GSE75367,GSE86978) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | positively-E |
| Experimental method for lncRNA-target : | RIP;luciferase reporter assay;RNAi |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell proliferation(+);cell invasion(+) |
| Regulatory Mechanism : | ceRNA(miR-124) |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Sustained Angiogenesis |
| Disease Category : | Cancer |
| Disease Name2 : | Lung cancer |
| Regulator Type : | lncRNA |
| Target Type : | TF |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000185591 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 6667 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells;HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124 |
| PubMedID : | 29034803 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | SP1 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 20.43487527 | 0.001092139 | 0.994877888 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 29.92387455 | -0.221744893 | 1.28e-07 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 24.98596389 | 0.149760489 | 0.71086294 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 25.62819271 | 0.776415994 | 1.99e-06 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 19.24798771 | -0.162022698 | 0.034896763 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 35.96218702 | 0.104707402 | 0.498687872 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 13.21026836 | 0.718037215 | 0.000818145 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 21.48071446 | -0.267226891 | 0.0009009 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 12.38477726 | -0.021410128 | 0.823685894 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 27.7026572 | 0.190797381 | 5.39e-05 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 28.41783762 | 0.568936444 | 2.66e-09 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 8.891325884 | 0.004899578 | 0.949240462 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 18.91991361 | -0.045692908 | 0.518270116 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 21.51361649 | 0.06379345 | 0.295735346 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 22.48270913 | 0.153459883 | 0.805935952 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 9.822376803 | -0.546518912 | 0.107487588 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 18.0972209 | -0.192549275 | 0.004075259 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 19.29896664 | -0.051508028 | 0.74106352 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 17.99401749 | 0.24675663 | 0.71059513 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 20.33256071 | -0.282392271 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 29.29676626 | 0.148500437 | 0.04964078 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 15.7957138 | 0.058297138 | 0.224598941 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 21.18495048 | -0.132474676 | 0.890225306 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 17.5015188 | -0.312033388 | 5.38e-05 |
Copyright © 2019 College of Bioinformatics Science and Technology, Harbin Medical University All rights reserved.
黑ICP备2022004059号