| Disease Name : | Uveal melanoma |
| Regulator : | HOXA11-AS |
| Target : | CDKN1A |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | UP(LIHC,PAAD,PRAD,BRCA);DATA(GSE117623,GSE40174,GSE104209,GSE109761,GSE75367,GSE86978) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | negatively-E |
| Experimental method for lncRNA-target : | RIP;ChIP |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell proliferation(+);cell invasion(+) |
| Regulatory Mechanism : | histone modification |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Insensitivity to Antigrowth Signals;Tissue Invasion and Metastasis |
| Disease Category : | Cancer |
| Disease Name2 : | Uveal cancer |
| Regulator Type : | lncRNA |
| Target Type : | PCG |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000124762 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 1026 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | LncRNA HOXA11-AS Exerts Oncogenic Functions by Repressing p21 and miR-124 in Uveal Melanoma;we demonstrated that HOXA11-AS functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS.Mechanistically, RNA immunoprecipitation demonstrated that HOXA11-AS could simultaneously interact with enhancer of zeste homolog 2 (EZH2) to suppress its target p21 protein expression. |
| PubMedID : | 28749709 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | CDKN1A | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 123.746743 | -1.604109109 | 2.58e-09 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 54.98332457 | -0.432945213 | 2.3e-05 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 180.5200937 | -0.245517318 | 0.794905509 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 109.9561302 | -0.688736228 | 0.072438932 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 79.92626964 | -1.166714275 | 8.68e-14 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 82.9007361 | -0.390264262 | 0.330512608 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 102.597028 | 1.574483273 | 0.003841375 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 185.5904186 | 0.047968229 | 0.772345848 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 60.44255539 | -0.400925973 | 0.190696193 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 113.7269013 | 0.617700027 | 2.52e-08 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 170.897996 | 1.310403918 | 1.84e-13 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 70.65386308 | -0.726680086 | 4.42e-05 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 61.67730222 | -0.949328681 | 2.99e-15 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 90.10775799 | -0.942822529 | 3.08e-13 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 100.260063 | 0.090044348 | 0.933741373 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 103.8369348 | 0.52399331 | 0.501285024 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 53.36497024 | -0.525901657 | 0.00126678 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 68.4301542 | -1.044023816 | 0.000829103 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 115.7880744 | 0.827683108 | 0.590538345 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 87.60258819 | 1.098394912 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 51.21163985 | -1.415775833 | 1.35e-17 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 153.1238884 | 1.099452734 | 4.86e-17 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 23.74850998 | -0.196386573 | 0.938389697 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 78.08389552 | 0.094169729 | 0.7275202 |
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