| Disease Name : | Malignant glioma |
| Regulator : | HOXA11-AS |
| Target : | miR-140-5p |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | |
| Regulatory Type : | binding/interaction |
| Level Of Regulation : | RNA-RNA |
| Regulation Direction : | negatively-F |
| Experimental method for lncRNA-target : | luciferase reporter assay;RNAi |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | tumorigenesis(+) |
| Regulatory Mechanism : | sponge |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | |
| Disease Category : | Cancer |
| Disease Name2 : | Brain glioma |
| Regulator Type : | lncRNA |
| Target Type : | miRNA |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Long Noncoding RNA HOXA11-AS Functions as miRNA Sponge to Promote the Glioma tumorigenesis Through Targeting miR-140-5p;Bioinformatics prediction forecast that miR-140-5p directly targeted HOXA11-AS at 3'-UTR, which was confirmed by luciferase reporter assay;In vitro rescue experiment assays, miR-140-5p inhibitor transfection, could reverse the function of HOXA11-AS knockdown on the proliferation, cell cycle arrest, and apoptosis |
| PubMedID : | 28832185 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | miR-140-5p | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | NA | NA | NA |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | NA | NA | NA |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | NA | NA | NA |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | NA | NA | NA |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | NA | NA | NA |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | NA | NA | NA |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | NA | NA | NA |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | NA | NA | NA |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | NA | NA | NA |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | NA | NA | NA |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | NA | NA | NA |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | NA | NA | NA |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | NA | NA | NA |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | NA | NA | NA |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | NA | NA | NA |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | NA | NA | NA |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | NA | NA | NA |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | NA | NA | NA |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | NA | NA | NA |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | NA | NA | NA |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | NA | NA | NA |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | NA | NA | NA |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | NA | NA | NA |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | NA | NA | NA |
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