| Disease Name : | Malignant glioma |
| Regulator : | HOXA11-AS |
| Target : | EZH2 |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | UP(PAAD);DOWN(PRAD,PAAD,BRCA);DATA(GSE40174,GSE104209,GSE60407,GSE111842) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | positively-E |
| Experimental method for lncRNA-target : | RNAi;luciferase reporter assay |
| Expression Pattern : | upregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell growth(+);cell invasion(+);cell migration(+) |
| Regulatory Mechanism : | ceRNA(miR-214-3p) |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Self Sufficiency in Growth Signals;Insensitivity to Antigrowth Signals;Tissue Invasion and Metastasis |
| Disease Category : | Cancer |
| Disease Name2 : | Brain glioma |
| Regulator Type : | lncRNA |
| Target Type : | PCG |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000106462 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 2146 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | ENX-1|ENX1|EZH2b|KMT6|KMT6A|WVS|WVS2 |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells;HOXA11-AS functioned as a competing endogenous RNA (ceRNA) for miR-214-3p, which in turn positively regulated the expression of its direct target EZH2 |
| PubMedID : | 28946213 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | EZH2 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 15.34266612 | 1.708557556 | 5.46e-14 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 14.50356896 | 2.323836402 | 6.87e-143 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 29.73580731 | 4.504366403 | 2.12e-29 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 8.239195159 | 2.390851028 | 3.04e-20 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 17.02290316 | 1.264995574 | 5.06e-52 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 16.01189518 | 1.602256225 | 3.56e-13 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 23.45029395 | 4.573311376 | 1.3e-30 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 14.73602817 | 0.694006032 | 3.75e-07 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 1.961629799 | 1.110112136 | 1.91e-06 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 4.235714952 | 1.815616637 | 1.87e-90 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 3.789397794 | 1.952564613 | 6.42e-45 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 5.822454317 | 2.407875778 | 1.42e-62 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 10.62723059 | 2.546130482 | 2.17e-88 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 18.93495935 | 3.173570682 | 1.21e-159 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 6.519627764 | 0.267409772 | 0.786227871 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 2.264603797 | 0.40728244 | 0.55881022 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 3.653078172 | 1.426845358 | 8.93e-37 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 16.74467505 | 1.182381049 | 3.69e-10 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 17.66303148 | 2.978057999 | 0.003990684 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 13.91578789 | 0.005953314 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 11.95414332 | 1.353275887 | 2.92e-20 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 2.484842369 | 0.498165537 | 3.87e-05 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 30.45547715 | -0.195567953 | 0.94199652 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 12.5761857 | 2.552456199 | 9.82e-77 |
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