| Disease Name : | Pre-eclampsia |
| Regulator : | HOXA11-AS |
| Target : | HOXA7 |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | positively-E |
| Experimental method for lncRNA-target : | RIP;ChIP;luciferase reporter assay |
| Expression Pattern : | downregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell proliferation(-) |
| Regulatory Mechanism : | ceRNA(miR-15b-5p) |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Insensitivity to Antigrowth Signals |
| Disease Category : | Cardiovascular system disease |
| Disease Name2 : | Eclampsia |
| Regulator Type : | lncRNA |
| Target Type : | TF |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000122592 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 3204 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | ANTP|HOX1|HOX1.1|HOX1A |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Downregulated lncRNA HOXA11-AS Affects Trophoblast Cell Proliferation and Migration by Regulating RND3 and HOXA7 Expression in PE.In the cytoplasm, HOXA11-AS modulates HOXA7 expression by sponged miR-15b-5p,affecting trophoblast cell proliferation. |
| PubMedID : | 30195759 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | HOXA7 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 7.207250602 | 0.047433427 | 0.915708273 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 3.463956402 | -1.847687947 | 2.89e-32 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 8.356111481 | 0.340470626 | 0.79238117 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 0.367886259 | 1.13704243 | 0.178497498 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 16.25884287 | -0.080353003 | 0.742656717 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 8.601085272 | 1.08558804 | 0.091378706 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 11.13678074 | 11.34812255 | 3.56e-18 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 4.433532281 | 1.3341374 | 3.03e-05 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 22.34547832 | 0.373968408 | 0.296255249 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 7.524925733 | -1.404332268 | 2.83e-23 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 16.98879658 | -0.276834479 | 0.224581236 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 0.206745721 | 2.272383819 | 1.28e-09 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 1.391990332 | -0.683503132 | 0.000376896 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 4.008512585 | 0.661853817 | 0.005551009 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 0.88573055 | 0.248634817 | 0.912587417 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 22.66810799 | 0.185723813 | 0.903117973 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 2.36406812 | -1.15481822 | 2.78e-16 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 13.84347867 | -0.000894375 | 0.998937468 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 9.747968859 | -0.684501142 | 0.743551446 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 3.856602717 | 1.684349242 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 2.788878229 | -0.761216362 | 0.027199097 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 0.201094795 | -0.899503724 | 7.64e-05 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 4.325091035 | 1.402161554 | 0.64886101 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 7.213467906 | -0.12693104 | 0.779836594 |
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