| Disease Name : | Pre-eclampsia |
| Regulator : | HOXA11-AS |
| Target : | RND3 |
| Clinical application : | |
| Regulator dysregulation in Circulating Tumor Cells : | |
| Target dysregulation in Circulating Tumor Cells : | UP(LIHC,NSCLC,SKCM,BRCA);DATA(GSE117623,GSE74639,GSE38495,GSE109761,GSE111065,GSE55807) |
| Regulatory Type : | regulation |
| Level Of Regulation : | |
| Regulation Direction : | negatively-E |
| Experimental method for lncRNA-target : | RIP;ChIP;luciferase reporter assay |
| Expression Pattern : | downregulation |
| Experimental method for lncRNA expression : | qPCR |
| Data Accession : | |
| Influenced Function : | cell proliferation(-);cell migration(-) |
| Regulatory Mechanism : | histone modification |
| Drugs : | |
| Cancer Stem Cell : | |
| Hallmark : | Insensitivity to Antigrowth Signals;Tissue Invasion and Metastasis |
| Disease Category : | Cardiovascular system disease |
| Disease Name2 : | Eclampsia |
| Regulator Type : | lncRNA |
| Target Type : | PCG |
| Regulator EnsembleID : | ENSG00000240990 |
| Target EnsembleID : | ENSG00000115963 |
| Regulator EntrezID : | 221883 |
| Target EntrezID: | 390 |
| RegulatorAlias : | HOXA-AS5|HOXA11-AS1|HOXA11AS|HOXA11S|NCRNA00076 |
| TargetAlias : | ARHE|Rho8|RhoE|memB |
| Regulator Location : | GRCh38_7:27184507-27189298 |
| Target Location : | |
| Evidence : | Downregulated lncRNA HOXA11-AS Affects Trophoblast Cell Proliferation and Migration by Regulating RND3 and HOXA7 Expression in PE.Mechanistic analyses showed that HOXA11-AS could recruit Ezh2 and Lsd1 protein and regulate RND3 mRNA expression in the nucleus |
| PubMedID : | 30195759 |
| Cancer Type(Tumour VS Normal) | HOXA11-AS | RND3 | ||||
|---|---|---|---|---|---|---|
| Mean Expression | log2FoldChange | FDR | Mean Expression | log2FoldChange | FDR | |
| BLCA(414 vs 19) | 5.99644655 | -0.646221521 | 0.123066692 | 38.69950413 | -1.629929845 | 2.12e-09 |
| BRCA(1142 vs 114) | 0.585994699 | 1.413713297 | 1.53e-14 | 26.25264066 | -1.359054917 | 2.06e-36 |
| CESC(306 vs 3) | 4.305793932 | -2.464538099 | 0.039739904 | 55.93845641 | 0.777031239 | 0.383273574 |
| CHOL(36 vs 9) | 0.237821927 | 2.538278537 | 0.070345516 | 23.7845374 | -2.672466687 | 5.04e-13 |
| COAD(505 vs 41) | 16.70122817 | -0.051829466 | 0.829663877 | 20.82077294 | -0.434569559 | 7.52e-05 |
| ESCA(185 vs 13) | 2.966320372 | 2.383333983 | 0.000794526 | 43.17605863 | -0.330995838 | 0.414702129 |
| GBM(170 vs 5) | 1.315368863 | 8.04661709 | 1.11e-08 | 30.69390631 | 1.69830739 | 0.000518755 |
| HNSC(522 vs 44) | 0.714959673 | 4.623922516 | 4.14e-32 | 72.94037647 | -0.740000941 | 1.67e-06 |
| KICH(66 vs 25) | 3.39017003 | 0.861142659 | 0.044350822 | 12.30577877 | -0.246057628 | 0.461358251 |
| KIRC(546 vs 72) | 0.784804166 | -1.316599371 | 4.43e-13 | 23.91831631 | 0.343975923 | 0.000606526 |
| KRIP(291 vs 32) | 1.891637586 | -0.342746437 | 0.477789077 | 25.80160266 | 1.124958632 | 7.15e-11 |
| LIHC(374 vs 50) | 0.246463613 | 4.949600743 | 3.73e-22 | 14.61784007 | -2.508098743 | 1.07e-48 |
| LUAD(542 vs 59) | 0.372353217 | 4.008716371 | 2.51e-17 | 18.26088311 | -0.459256381 | 0.003412092 |
| LUSC(504 vs 51) | 1.301451556 | 6.235710512 | 3.91e-70 | 47.08485737 | 0.734816928 | 4.35e-08 |
| PAAD(179 vs 4) | 1.223067318 | 2.87549756 | 0.157179803 | 26.96063181 | 0.145590015 | 0.902988979 |
| PCPG(184 vs 3) | 0.454624793 | -1.880486916 | 0.328935542 | 7.568626228 | -2.488029638 | 0.007960371 |
| PRAD(506 vs 52) | 57.07931304 | 0.824046147 | 5.91e-08 | 13.89217569 | -1.256644992 | 4.76e-16 |
| READ(167 vs 10) | 15.29943582 | 0.18966394 | 0.754429453 | 20.79145149 | -0.570854608 | 0.019608396 |
| SARC(263 vs 2) | 7.339992625 | -1.023868826 | 0.759376034 | 48.55275671 | 0.105065602 | 0.969065731 |
| SKCM(472 vs 1) | 2.324511658 | 2.555662817 | 0.999958931 | 30.96849269 | 1.900708522 | 0.999958931 |
| STAD(416 vs 37) | 3.146020421 | 3.63825029 | 3.17e-18 | 17.06942988 | -0.840908163 | 1.21e-07 |
| THCA(513 vs 59) | 0.176132299 | 3.448179082 | 1.98e-17 | 8.791054543 | 0.081626772 | 0.669468717 |
| THYM(120 vs 2) | 0.077780159 | 0.403209995 | 0.937612178 | 11.72120154 | -0.22415452 | 0.944267876 |
| UCEC(558 vs 35) | 6.650659658 | -1.237521882 | 0.000170051 | 19.78419994 | -0.834371088 | 1.14e-05 |
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